Ras/Mapk Activation in Triple-Negative Breast Cancers (Tnbcs) Is Associated With Lower Levels of Tumor Lymphocytic Infiltration and Poorer Survival

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

S Dushyanthen, ZL Teo, F Caramia, P Savas, CP Mintoff, B Virassamy, MA Henderson, SJ Luen, M Mansour, MH Kershaw, JA Trapani, PJ Neeson, R Salgado, GA McArthur, JM Balko, PA Beavis, PK Darcy, S Loi

2017-12-01

The presence of tumor-infiltrating lymphocytes in triple-negative breast cancers is correlated with improved outcomes. Ras/MAPK pa..